Well, we do know Roman Reign has cancer. Silver King collapsed in the ring and died after a heart attack. There's this one dude who lost both legs in AEW. For depression, we have Benoit. I do know one guy who used to worked for WWE for a while who was disabled after taking a risk pump but I forgot his name. Of course, there's Takayama who is probably never able to walk again. We have Hornswoggle as a dwarf. I dont know if there is an albino wrestler thou. As for CTE, anyone who have taken multiple pumps probably have it. Benoit also had CTE, so does Jimmy Snuka. In fact, it is more like "who doesnt have CTE rather than who has it".
As for me, I only want to see the top wrestler of your company got into an accident, lost his leg, got depressed then offed himself. It's a tragic story but very realistic if you think about it. There's a Japanese wrestler who always bring a death letter with him to work. The letter says that if he die in the match, his opponent shouldnt feel guilty because his health was very bad to begin and he also sorry for being inconvenience.