There's a few minor things to turn off and a major one.
The absolute major thing to turn off is Strict Storylines. Even veterans of the series have issues with this one. I feel like it stifles creativity, and makes me anxious and reliant on the "money" angles that I stop booking stories how I think they should be told.
The minor ones are: Overuse Penalties, Production Effects, and Worker Morale, in my opinion.
Please don't turn off Crowd Management as someone suggested. That is the fabric of the game that you should learn. But you can't just try to learn it willy nilly-- you need to make an effort to see what works. Crowd Management is how you create flow to your shows, and manipulate the crowd. The basic idea is that you hook them with really exciting stuff, then with boring stuff, then with exciting stuff, then boring stuff, then blow them away with amazing stuff. There's a lot of depth to it that should be practiced. Go over the results of WrestleMania X-Seven to see an example of how to do this. It's implemented amazingly well in this game.
Don't turn off match ratios either, or booking times. You're not dumb. That is so easy to understand.
The biggest thing is just to accept that you'll suck and use the editor to fix your issues. If you lose popularity and money, edit those and move forward. Just keep playing and playing lots of games.